产品描述:
The fatty acid binding proteins (FABPs) 5 and 7 have been identified as intracellular transporters for the endocannabinoid anandamide.{17092} They are thought to be required for transport of anandamide through the cytoplasm to the endoplasmic reticulum for degradation by fatty acid amide hydrolase. SB-FI-26 is an α-truxillic acid 1-naphthyl mono-ester derived from incarvillateine (I. sinensis) that inhibits FABP5 binding to NBD-stearate in an in vitro displacement assay with a Ki value of 0.9 μM.{22111} At 20 mg/kg, i.p., SB-FI-26 has been reported to have antinociceptive and anti-inflammatory effects in several mouse models of pain.{22111}