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Clasto-Lactacystin β-lactone
品牌： Cayman
产品货号： 70988-50 µg
规格： 50 µg

报价：
折后价：

数量： - +
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  • 产品名称:
    Clasto-Lactacystin β-lactone
  • 别名:
    Omuralide|β-Clastolactacystin
  • 产品描述:
    Lactacystin is a microbial metabolite isolated from Streptomyces that is now widely used as a selective inhibitor of the 20S proteasome.{10086,2351,10073} Clasto-lactacystin β-lactone was later identified as the active metabolite of lactacystin, resulting from the elimination of cysteine and the formation of a reactive β-lactone. Both lactacystin and its β-lactone metabolite induce differentiation and inhibit cell cycle progression in several tumor cell lines.{1659} Clasto-lactacystin β-lactone irreversibly alkylates subunit X of the 20S proteasome.{10073} It is at least 10 times more active than the parent compound; this increased activity may be a function of increased cell permeability. Inhibition of proteasome peptidase activity results in the accumulation of a variety of ubiquitinated proteins which would normally undergo rapid degradation. Thus, the effects of clasto-lactacystin β-lactone are pleiotropic and depend substantially on the expression pattern of signaling proteins within the treated cell.
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  • 保存温度:
    -20
  • 运输温度:
    -20
  • 细胞定位:
  • 预期分子量:
    213.2
  • 产品形式:
    A solution in methyl acetate
  • 存储溶液:
  • 有效期:
    730
  • 产地:
    美国
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  • 纯度:
    ≥95%
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  • CAS号:
    154226-60-5
  • 分子式:
    C10H15NO4
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