产品描述:
BMS 963272 is an inhibitor of monoacylglycerol acyltransferase 2 (MGAT-2; IC50 = 7.1 nM).{64146} It is selective for MGAT-2 over MGAT-3, acyl-CoA wax alcohol acyltransferase 2 (AWAT2), and diacylglycerol acyltransferase 2 (DGAT-2; IC50s = >33 µM for all). In vivo, BMS 963272 (30 mg/kg) reduces body weight gain and food intake in a wild-type but not Mogat2-/- mouse model of high-fat diet-induced obesity. BMS 963272 (0.3 and 3 mg/kg) reduces plasma alanine transaminase (ALT), aspartate aminotransferase (AST), and bile acid levels and hepatic fibrosis in a mouse model of non-alcoholic steatohepatitis (NASH) induced by a choline-deficient and high-fat diet (CDAHFD).{65912}