产品描述:
Acetazolamide-d3 is intended for use as an internal standard for the quantification of acetazolamide by GC- or LC-MS. Acetazolamide is an inhibitor of carbonic anhydrase I (CAI), CAII, CAIX, and CAXII (Kis = 310, 12, 25, and 5.7 nM, respectively, for the human enzymes).{36212} It inhibits the migration and invasion of Caki-1, Caki-2, and ACHN renal carcinoma cells when used at a concentration of 10 µM.{72187} Acetazolamide (5.6 mg/kg per day) increases currents in calcium-activated potassium channels in patch clamp assays using skeletal muscle tissues isolated from potassium-deficient rats.{36214} It induces vasodilation and increases cerebral, renal, and hepatic blood flow and blood oxygen levels in normotensive rabbits when administered at a dose of 12 mg/kg.{72188} Formulations containing acetazolamide have been used in the treatment of edema, open-angle glaucoma, epilepsy, and acute mountain sickness.