产品描述:
Maribavir is an antiviral agent.{24642} It inhibits human cytomegalovirus (CMV) pUL97 protein kinase (IC50 = 3 nM). Maribavir inhibits the replication of clinical isolates of CMV, including those resistant to ganciclovir (Item No. 37487), in infected MRC-5 human lung fibroblasts (IC50s = 0.03-0.13 µM). Oral administration of maribavir (25 or 75 mg/kg) decreases CMV titers in a mouse model of ocular CMV infection following implantation of human fetal retinal tissue.{66616} Formulations containing maribavir have been used in the treatment of post-transplant CMV infections.