产品描述:
J27644 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 10 nM).{72123} It is selective for HDAC6 over HDAC1-5 (IC50s = 211-516 nM) and HDAC7, -8, -9, and -11 (IC50s = 137-812 nM). J27644 (10 µM) reduces the level of proteins involved in fibrosis, including collagen 1A1, α-smooth muscle actin (α-SMA), and fibronectin, in human pulmonary fibroblasts in vitro.