产品描述:
Ferroptocide is an inhibitor of thioredoxin (Trx) and a derivative of pleuromutilin (Item No. 19452).{67521} It inhibits Trx activity in ES-2 ovarian cancer cells when used at a concentration of 20 µM and is cytotoxic to ES-2 cells (IC50 = 1.6 µM). Ferroptocide (5 µM) induces ferroptosis in ES-2 cells, an effect that can be blocked by the iron chelator deferoxamine (DFO; Item No. 14595), antioxidant Trolox (Item No. 10011659), or ferroptosis inhibitor ferrostatin-1 (Item No. 17729). It decreases tumor volume in a 4T1 murine mammary carcinoma model using immunocompetent but not immunodeficient mice when administered at 50 mg/kg twice per week.