产品描述:
DMU2105 is an inhibitor of the cytochrome P450 (CYP) isoform CYP1B1 (IC50 = 0.01 µM).{72079} It is selective for CYP1B1 over CYP1A1, CYP1A2, CYP3A4, and CYP2D6 (IC50s = 0.742, 1.2, 18, and 10 µM, respectively). DMU2105 enhances cisplatin-induced cell death in HEK293 cells overexpressing CYP1B1.