产品描述:
(E/Z)-IT-603 is a c-Rel inhibitor (IC50 = 3 µM).{72125} It inhibits c-Rel DNA binding to the IL2 promoter in an EMSA. (E/Z)-IT-603 reduces the proliferation of OCI-Ly3 diffuse large B cell lymphoma cells (IC50 = 18 µM). It reduces Huh7 epithelial carcinoma spheroid growth when used at a concentration of 20 µM in combination with the anthracycline antitumor antibiotic doxorubicin (Item No. 15007).{72126} Preincubation of (E/Z)-IT-603 (20 µM) with murine T cells co-administered with A20 murine lymphoma cells to lethally irradiated mice as a model of T cell-depleted bone marrow transplantation reduces allo-stimulation without affecting anticancer T cell responses and increases survival.{72125} In vivo, (E/Z)-IT-603 (24 mg/kg every other day), when used in combination with doxorubicin, reduces hepatic tumor burden, increases CD8+ T cell and F4/80+ macrophage tumor infiltrates, and increases tumoral mRNA encoding chemokine (C-X-C motif) ligand 9 (Cxcl9) in a Hep-53.4 murine hepatocellular carcinoma model.{72126}