产品描述:
Azvudine is a nucleoside reverse transcriptase inhibitor (NRTI).{68537} It reduces viral infectivity in HIV-1-infected HEK293T cells (EC50 = 0.063 nM) and reduces viral replication in 2209-23 cells stably transfected with hepatitis C virus (HCV) genotype 1b (EC50 = 24 nM).{68537,68538} In vivo, azvudine (0.7 mg/kg) reduces viral load and the number of lung ground-glass opacities observed via chest X-ray in a rhesus macaque model of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.{68539}