产品描述:
Bax channel blocker is an inhibitor of Bax.{69537} It binds to Bax in a cell-free assay (Kd = 15 µM) and inhibits Bax-mediated membrane permeabilization induced by the membrane-targeted death ligand tBID in a liposomal release assay (IC50 = 3.3 µM). Bax channel blocker inhibits apoptosis induced by TNF-α- and the protein synthesis inhibitor cycloheximide (Item No. 14126) in mouse embryonic fibroblasts (MEFs; IC50 = 1.8 µM). It also inhibits cell death induced by the Bax activator BTSA1 (Item No. 37305) in OCI-AML-3 cells.