产品描述:
Acemetacin is a non-steroidal anti-inflammatory drug (NSAID) and a prodrug form of indomethacin (Item No. 70270).{48888} It reduces zymosan-induced thromboxane B2 (TXB2; Item No. 19030) and prostaglandin E2 (PGE2; Item No. 14010) production in isolated rat whole blood and stomach, respectively, when administered at doses ranging from 2.7 to 83.8 µmol/kg. Acemetacin (1.3, 2.5, and 10 mg/kg) also reduces carrageenan-induced PGE2 production in rat synovial membranes.{48889} It decreases leukocyte infiltration in the exudate in a rat model of zymosan-induced air pouch inflammation when administered at doses of 27.9 and 83.8 µmol/kg.{48888}