产品描述:
Calmodulin is a calcium-sensing protein that regulates a wide array of proteins involved in diverse cellular functions.{23722,24947} Ophiobolin A is a sesterterpenoid fungal phytotoxin that binds and irreversibly antagonizes calmodulin, blocking the activation of calmodulin-dependent phosphodiesterase with an IC50 value of 9 μM.{24945} It antagonizes a variety of forms of calmodulin from plants and animals by binding covalently to conserved lysine residues.{24948,24946}