产品描述:
Lithospermic acid is a polyphenol that has been found in S. miltiorrhiza and has diverse biological activities.{62145,62146} It inhibits xanthine oxidase (IC50 = 5.2 µg/ml) and scavenges DPPH (Item No. 14805) radicals in cell-free assays (IC50 = 23.2 µg/ml). It also inhibits the production of reactive oxygen species (ROS) induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) in isolated human neutrophils in a concentration-dependent manner.{62145} Lithospermic acid inhibits 3'-processing and 3'-joining to target DNA by HIV-1 integrase in cell-free assays (IC50s = 0.83 and 0.48 µM, respectively).{62147} It also inhibits acute HIV-1 infection of H9 human lymphoma cells (IC50 = 2 µM) without inducing cytotoxicity. Lithospermic acid (100 mg/kg) prevents carbon tetrachloride-induced hepatic necrosis in mice.{62146}