产品描述:
BAY-293 is an inhibitor of the protein-protein interaction between K-Ras and the guanine nucleotide exchange factor son of sevenless homolog 1 (SOS1; IC50 = 0.021 µM).{54879} It inhibits proliferation of K562 and MOLM-13 cells expressing wild-type K-Ras, as well as NCI H358 and Calu-1 cells expressing mutant K-RasG12C with IC50 values of 1.09, 0.995, 3.48, and 3.19 µM, respectively.