产品描述:
MX69 is an inhibitor of the interaction between the ubiquitin ligase MDM2 protein and XIAP mRNA.{45164} It binds to the RING domain of MDM2 (Kd = 2.34 µM) and decreases the levels of MDM2 and XIAP in a concentration-dependent manner without affecting the levels of Bcl-2, cIAP-1, and cIAP-2. It induces autoubiquitination and degradation of MDM2 and increases the half-life of p53 in EU-1 cells. MX69 is cytotoxic to a variety of acute lymphoblastic leukemia (ALL) and neuroblastoma cancer cell lines but not to human normal bone marrow mononuclear (NBMM) cells. It increases survival in an EU-1 mouse model of leukemia when administered at a dose of 100 mg/kg.