产品描述:
MIV-150 is a tight-binding, allosteric inhibitor of reverse transcriptase that is active against HIV-1 and HIV-2 (both EC50s = 1 nM in vitro).{29583} It has been shown to inactivate viruses that are resistant to other antiviral drugs, including non-nucleoside reverse transcriptase inhibitors, nucleoside reverse transcriptase inhibitors, and protease inhibitors.{29583} Although MIV-150 possesses poor oral bioavailability, it demonstrates efficacy when formulated as a topical microbicide.{29585,29584}