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Kdo2-Lipid A (ready-to-use)
品牌: Adipogen
产品货号: AG-CU1-0001-M001
规格: 1 mg

报价:
折后价:

数量: - +
产品详情
* 以下信息仅供参考,详情请以原厂网站为准
  • 产品名称:
    Kdo2-Lipid A (ready-to-use)
  • 别名:
    (3-Deoxy-D-manno-octulosonic acid)2-Lipid A
  • 产品描述:
    Defined substructure of the Re mutant of lipopolysaccharide (LPS) [1]. Endotoxin activity equal to Re LPS [1]. Strong activator (<10ng/ml) of macrophages via toll-like receptor 4 (TLR4) [1, 2, 3, 4, 9]. Does not activate TLR2 [5] or other TLRs as determined with splenocytes and macrophages from TLR4 deficient mice by IL-6 ELISA [1,4]. Facilitates the structural analysis of its complexes with signaling receptors, such as TLR4/MD2 [1,2] and CD14 [7]. Kdo2-Lipid A was used in a recent animal atherosclerosis model [6]. Induces sphingolipid biosynthesis, which is essential for induction of autophagy [8].
  • 反应种属:
  • 宿主来源:
    Isolated and purified from E. coli K12 heptose-deficient strain WBB06 (Re mutant).
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  • 产品浓度:
    0.5mg/ml. Vial contains 2 ml.
  • 表达系统:
  • 阳性对照:
  • 保存温度:
    +4°C
  • 运输温度:
    Ambient
  • 细胞定位:
  • 预期分子量:
    2326.7
  • 产品形式:
    liquid
  • 存储溶液:
    Liquid. Sterile, ready-to-use solution in pyrogen-free double distilled water.
  • 有效期:
    Stable for at least 2 years after receipt when stored at +4°C.
  • 产地:
    瑞士
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  • 样本类型:
    Liquid. Sterile, ready-to-use solution in pyrogen-free double distilled water.
  • 产品特点:
  • 纯度:
    Absence of detectable protein or DNA contaminants with agonistic TLR activity.
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  • CAS号:
    123621-04-5 (free base)
  • 分子式:
    C110H198N2Na4O39P2
  • 溶解度:
  • PubChem CID:
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