产品描述:
Chonglou saponin VII is a steroid saponin that has been found in P. polyphylla and has anticancer activities.{68545,68546} It inhibits the proliferation of HepG2 cells and HepG2 cells resistant to doxorubicin (HepG2/ADR cells) when used at concentrations of 1.98 and 2.97 µM. Chonglou saponin VII (1.98 µM) reduces ADR resistance in HepG2/ADR cells when administered in combination with ADR, an effect that is enhanced by the addition of the PI3K inhibitor LY294002 (Item No. 70920) and the p38 MAPK inhibitor SB203580. It also inhibits the proliferation of MDA-MB-231, MDA-MB-436, and MCF-7 breast cancer cells (IC50s = 3.16, 3.45, and 2.86 µM, respectively).{68546} It induces apoptosis and autophagosome formation in the same cells. Chonglou saponin VII (1.5 mg/kg) induces intratumoral autophagy and reduces tumor growth in an MDA-MB-231 mouse xenograft model.{68546}