产品描述:
Propionic acid-d5 is intended for use as an internal standard for the quantification of propionic acid by GC- or LC-MS. Propionic acid is a short-chain fatty acid.{52278} It is produced predominately by bacterial fermentation of dietary fiber in the colon but is also found in various dairy products such as yogurt.{52278,72097} Propionic acid is an agonist of free fatty acid receptor 2 (FFAR2/GPR43) and FFAR3/GPR41.{25606} It inhibits forskolin-induced cAMP accumulation in CHO-K1 cells expressing FFAR2/GPR43 or FFAR3/GPR41 (EC50s = 14 and 6.2 µM, respectively) and induces chemotaxis of polymorphonuclear (PMN) neutrophils when used at a concentration of 1 mM. Propionic acid inhibits the proliferation of isolated mouse splenic B lymphocytes induced by concanavalin A (Item No. 14951) or LPS (IC50s = 6.6 and 4.6 mM, respectively).{72098} It is active against P. aeruginosa, E. coli, K. pneumoniae, and P. mirabilis when used at a concentration of 20 mM.{72099} Subgingival plaque levels of propionic acid are increased in patients with severe gingivitis.{72100}