产品描述:
5,7-Dimethoxyflavone (5,7-DMF) is a flavonoid that has been found in B. pandurata and has diverse biological activities.{51455,51454,51456} It induces the production of reactive oxygen species (ROS), cell cycle arrest at the G1 phase, and apoptosis in HepG2 liver cancer cells when used at concentrations of 10, 25, and 50 µM.{51454} In vivo, 5,7-DMF (75-150 mg/kg) reduces exudate volume and inhibits prostaglandin production in a rat model of carrageenan-induced pleurisy.{51455} It reduces rectal temperature in a rat model of yeast-induced hyperthermia. 5,7-DMF also reduces serum triglyceride, total cholesterol, and LDL levels, as well as increases serum insulin levels and reduces blood glucose levels in a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104).{51456}