产品描述:
Estradiol cypionate is a synthetic estrogen and an ester derivative of 17β-estradiol (Item No. 10006315).{54282,54283,54284} In vivo, estradiol cypionate (0.1 mg/kg per day) reduces estrogen depletion-induced spikes in basal tail temperature in ovariectomized wild-type, estrogen receptor α knockout (ERα-/-), and ERβ-/- mice.{54282} It increases the rate of pregnancy in cows induced to ovulate small dominant follicles with gonadotropin-releasing hormone (GnRH).{54283} Estradiol cypionate also reduces edema and articular joint neutrophil infiltration in an ovariectomized mouse model of zymosan-induced arthritis.{54284} Formulations containing estradiol cypionate have been used in the treatment of menopausal symptoms and low estrogen levels.