产品描述:
Hecogenin is a natural steroid sapogenin with diverse biological activities that was originally isolated from A. sisalana and has been used in the synthesis of steroids.{38813} It has antioxidant, anti-inflammatory, antiproliferative, and neuroprotective properties.{38814,38815,38816,38817} Hecogenin (10 μM) decreases superoxide anion formation induced by N-Formyl-Met-Leu-Phe (fMLP; Item No. 21495) in rat neutrophils by 23.6%.{38814} It also inhibits myeloperoxidase (MPO) release from human neutrophils activated by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) when used at a concentration of 1 μg/ml.{38815} Hecogenin inhibits proliferation of the breast cancer cell lines MDA-MB-231, MDA-MB-468, MCF-10A, MCF-7, T47D, BT474, and SK-BR-3 (IC50s = 28.7-38.2 μM).{38816} It decreases the number of glutamate-induced TUNEL-positive primary rat spinal motor neurons by 11% when used at a concentration of 1 μM.{38817} In vivo, hecogenin (15 mg/kg) decreases the mucosal lesion area of ethanol-induced gastric ulceration in mice.{38815} It also decreases tumor volume in an MDA-MB-231 human breast cancer mouse xenograft model when administered at a dose of 10 mg/kg three times per week.{38816}