产品描述:
HMN-176 is an anticancer agent and active metabolite of the prodrug HMN-214 (Item No. 26210).{43655} It is cytotoxic against a panel of cancer cell lines with a mean IC50 value of 112 nM, as well as P388 leukemia cells that are resistant to the DNA-crosslinking agent cisplatin (Item No. 13119), anthracycline antitumor antibiotic doxorubicin (Item No. 15007), or antimitotic vincristine (Item No. 11764) (IC50s = 143, 557, and 265 nM, respectively). HMN-176 (3 µM) induces cell cycle arrest at the G2/M phase in HeLa cervical cancer cells.