产品描述:
BRD0705 is an inhibitor of glycogen synthase kinase 3α (GSK3α; IC50 = 66 nM).{68302} It is selective for GSK3α over GSK3β (IC50 = 515 nM). BRD0705 (10 and 20 µM) inhibits GSK3α autophosphorylation in U937 cells. It impairs colony formation of MOLM-13, TF-1, U937, MV4-11, HL-60, and NB4 acute myeloid leukemia (AML) cells. In vivo, BRD0705 (30 mg/kg) inhibits leukemia development in secondary recipient mice in an MLL-AF9 mouse syngeneic tumor model.