产品描述:
BMS 502 is an inhibitor of diacylglycerol kinase α (DGK-α), DGK-ζ, and DGK-ι (IC50s = 0.0046, 0.0021, and 0.0026 µM, respectively).{49800} It is selective for these DGKs over DGK-β, DGK-γ, and DGK-κ (IC50s = 1, 0.68, and 4.6 µM, respectively). BMS 502 increases levels of IFN-γ and phosphorylation of ERK in isolated human whole blood (EC50s = 0.28 and 0.52 µM, respectively). It also increases the proliferation of CD8+ T cells (EC50 = 0.065 µM), which express DGK-α and DGK-ζ but not DGK-ι. BMS 502 (0.3-10 mg/kg) increases the frequency of CD69+CD8+ T cells when administered in combination with the peptide antigen SIINFEKL in OT I mice, which express modified murine T cell receptors that recognize SIINFEKL.