产品描述:
Vimseltinib is an inhibitor of colony stimulating factor 1 receptor (CSF1R; IC50 = 3.7 nM).{67444} It is selective for CSF1R over FMS-related tyrosine kinase 3 (FLT3), PDGFRα, PDGFRβ, and KIT (IC50s = >3,300, 436, 2,300, and 476 nM, respectively). Vimseltinib inhibits the proliferation of M-NFS-60 leukemia cells (IC50 = 18 nM). It inhibits CSF1-induced CFS1R autophosphorylation in THP-1 cells (IC50 = 27 nM) and CSF1- and RANKL-induced osteoclast differentiation (IC50 = 9.3 nM).