产品描述:
CAY10796 is an aminopyrazole ATP-competitive inhibitor of glycogen synthase kinase 3 (GSK3), with 34% inhibition when used at a concentration of 2.5 µM.{40152} It inhibits androgen receptor transactivation in 22Rv1, LNCaP, and LNCaP-SSR cell lines in a dose-dependent manner. It promotes nuclear export of the androgen receptor and decreases translocation to the nucleus in PC3 and PCa prostate cancer cells, respectively.{40152,40153} In HEK293 cells expressing the rat Nav1.2 channel, pretreatment with CAY10796 dose-dependently potentiates peak current densities.{40151}