产品描述:
PS-1145 is an IκB kinase β (IKKβ) inhibitor (IC50 = 88 nM).{23652} It selectively inhibits IKKβ over a panel of 14 kinases (IC50s = >100 nM for all). PS-1145 also inhibits the IKK complex (IC50 = 100 nM).{23654} It inhibits the proliferation of MM.1S, U266, and RPMI-8226 myeloma cells when used at concentrations ranging from 1.5 to 50 µM. PS-1145 inhibits TNF-α-induced activation of NF-κB in MM.1S cells in a concentration-dependent manner. It inhibits RANKL-induced differentiation of RAW 264.7 cells into osteoclasts when used at concentrations of 5 and 10 µM.{67116} PS-1145 (10 µM) inhibits RANKL-induced phosphorylation of IκBα, ERK, and JNK in RAW 264.7 cells.