产品描述:
Pachymic acid is a triterpenoid that has been found in P. cocos and has diverse biological activities.{59935,59936,59937,59938} It inhibits hexokinase 2 (HK2; IC50 = 5.01 µM), as well as reduces glucose uptake and lactate production in SK-BR-3 breast cancer cells.{59935} Pachymic acid inhibits IL-1β-induced cytosolic phospholipase A2 (cPLA2) activation and prostaglandin E2 (PGE2; Item No. 14010) production in, as well as inhibits the proliferation of, A549 lung cancer cells.{59936} It decreases tumor growth in an NCI H23 lung cancer mouse xenograft model when administered at doses of 30 and 60 mg/kg.{59937} Pachymic acid (10 and 20 mg/kg) prevents increases in serum urea and creatinine levels in a mouse model of renal ischemia-reperfusion injury.{59938}