产品描述:
LY2603618 is a checkpoint kinase 1 (Chk1) inhibitor (IC50 = 7 nM) that prevents the repair of DNA caused by DNA-damaging agents.{32250} It can inhibit Chk1 autophosphorylation and increase DNA damage-mediated Chk1 phosphorylation.{32251} LY2603618 has been used in xenograft tumor models to potentiate the antitumor efficacy of chemotherapeutic agents such as gemcitabine (Item No. 11690).{32249}