产品描述:
PH-797804 is an inhibitor of p38α MAPK with an IC50 value of 26 nM in a cell-free assay.{31975,21533} It is 4-fold more selective for p38α compared to p38β and does not inhibit JNK2 or ERK at concentrations up to 1 µM.{31975} PH-797804 treatment for 10 days in vivo demonstrates anti-inflammatory activity in chronic inflammatory disease models, significantly reducing both joint inflammation and associated bone loss in streptococcal cell wall-induced arthritis in rats and collagen-induced arthritis in mice.{31975}