产品描述:
HA-1100, a cell-permeable hydroxylated metabolite of HA-1077 (Item No. 10010559), is a potent inhibitor of Rho-associated kinase (ROCK) (Ki = 150 nM).{23184} It less effectively inhibits protein kinase A (Ki = 2.2 μM).{23184} It has been used to explore the role of ROCK in hypoxic and ischemic signaling as well as arterial relaxation.{23180,23181,23182,23183}