产品描述:
Binimetinib is a MEK1 and MEK2 inhibitor (IC50s = 1.8 and 0.92 nM, respectively).{46450} It is selective for MEK1/2 over a panel of RAF/MEK/ERK pathway kinases at 10 µM. Binimetinib reduces cell growth in HT-29, COLO 205, and LoVo colorectal cancer cell lines (IC50s = 0.48, 0.52, and 2.2 nM, respectively). It reduces tumor volume in a COLO 205 mouse xenograft model when administered at a dose of 0.3 mg/kg. Formulations containing binimetinib have been used in the treatment of various cancers.