产品描述:
BMS 582949 is an orally bioavailable p38α MAP kinase inhibitor (IC50 = 13 nM in an enzyme assay).{39188} It also inhibits TNF-α production in human peripheral blood mononuclear cells (PBMC; IC50 = 50 nM). When administered at a dose of 5 mg/kg in mice, it decreases LPS-induced TNF-α production up to 89% compared to vehicle. BMS 582949 reduces paw swelling in a rat adjuvant arthritis model when administered once per day (1, 10, or 100 mg/kg) or twice per day (1 or 5 mg/kg).