产品描述:
Pyridinylimidazoles, often termed CSAIDs, are a class of anti-inflammatory compounds that inhibit eicosanoid production and suppress the synthesis of cytokines in human monocytes.{16246} Because of its high specificity, one predominant pyridinylimidazole, SB203580, is frequently used to inhibit p38 MAPK, the tyrosine kinase activated by environmental stresses and inflammatory cytokines.{15737} CAY10571 is an analog of SB203580. It inhibits IL-1 production in the human monocytic cell line THP with an IC50 value of 0.20 µM and binds CSAID binding protein, a serine/threonine kinase homologous to p38, inhibiting its kinase activity with an IC50 value of 0.03 µM.{16229,13876} CAY105571 also inhibits 5-lipoxygenase production in RBL-1 cells with an IC50 value of 24 µM.{16229}