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17-phenyl trinor Prostaglandin F2α isopropyl ester
品牌： Cayman
产品货号： 16824-10 mg
规格： 10 mg

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数量： - +
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  • 产品名称:
    17-phenyl trinor Prostaglandin F2α isopropyl ester
  • 别名:
    17-phenyl trinor PGF2α isopropyl ester|17-phenyl trinor PGF2α-iPr|Bimatoprost isopropyl ester
  • 产品描述:
    17-phenyl trinor PGF2α N-ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name Bimatoprost.{8322} The N-ethyl amide prostaglandin prodrugs are converted to the active free acid more slowly than the analogous prostaglandin ester prodrugs such as latanoprost.{8941} This product is the isopropyl ester of the free acid prostaglandin which corresponds to Bimatoprost. The free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist.{9206} In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity. The 17-phenyl trinor PGF2α isopropyl ester derivative was examined for IOP-lowering activity during the development of latanoprost.{9311} At the dose of 3 μg/eye in the monkey, 17-phenyl trinor PGF2α isopropyl ester was the most potent analog tested in reducing IOP, lowering the IOP 1.3 mm Hg below the level achieved by latanoprost. However, this derivative was also significantly more irritating to the eye than latanoprost.{9311}
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  • 阳性对照:
  • 保存温度:
    -20
  • 运输温度:
    -20
  • 细胞定位:
  • 预期分子量:
    430.6
  • 产品形式:
    A solution in ethanol
  • 存储溶液:
  • 有效期:
    730
  • 产地:
    美国
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  • 纯度:
    ≥98%
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  • CAS号:
    130209-76-6
  • 分子式:
    C26H38O5
  • 溶解度:
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