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Kynurenine Aminotransferase II (human) (rec.) (His)
品牌： Adipogen
产品货号： AG-40T-0102-C050
规格： 50 ug

报价：
折后价：

数量： - +
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  • 产品名称:
    Kynurenine Aminotransferase II (human) (rec.) (His)
  • 别名:
    hKAT II; KAT2; alpha-Aminoadipate Aminotransferase (Mitochondrial); AADAT; EC 2.6.1.7
  • 产品描述:
    Kynurenine aminotransferases (KATs) are pyridoxal-5’-phosphate-dependent enzymes that catalyze the conversion of L-kynurenine into kynurenic acid, a neuroactive metabolite whose unbalancing is associated with a number of brain disorders. Biochemical and structural investigations revealed that L-kynurenine (L-KYN) recognition by hKAT II is achieved by exploiting structural features that are peculiar of this isoform, thus offering the possibility to select/design inhibitor molecules specifically targeting hKAT II to be used as modulators of kynurenic acid synthesis in the CNS. hKAT II is one of the aminotransferases involved in the pyridoxal 5'-phosphate (PLP)-dependent irreversible transamination of L-kynurenine (L-KYN) to kynurenic acid (KYNA) in the central nervous system. When assayed in vitro the protein also displays beta-elimination activity.
  • 反应种属:
  • 宿主来源:
    E. coli
  • 实验应用:
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  • 免疫原:
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  • 偶联:
  • 产品浓度:
    0.5mg/ml (Lot specific)
  • 表达系统:
  • 阳性对照:
  • 保存温度:
    -80°C
  • 运输温度:
    DRY ICE
  • 细胞定位:
  • 预期分子量:
    ~49.8kDa
  • 产品形式:
    liquid
  • 存储溶液:
    Liquid. In 50 mM phosphate buffer pH 8.0, containing 50mM sodium chloride and 40µM pyridoxal 5'-phosphate (PLP).
  • 有效期:
    Stable for at least 6 months after receipt when stored at -80°C.
  • 产地:
    瑞士
  • 外观:
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  • 检测方法:
  • 样本类型:
    Liquid. In 50 mM phosphate buffer pH 8.0, containing 50mM sodium chloride and 40µM pyridoxal 5'-phosphate (PLP).
  • 产品特点:
  • 纯度:
    >97% (SDS-PAGE)
  • 生物活性:
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