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GPX2 (human, recombinant)
品牌： Cayman
产品货号： 39630-100 µg
规格： 100 µg

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数量： - +
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  • 产品名称:
    GPX2 (human, recombinant)
  • 别名:
    Glutathione Peroxidase 2 (Gastrointestinal)|GSHPX2|GSHPX-GI
  • 产品描述:
    Glutathione peroxidase 2 (GPX2) is a selenocysteine-containing glutathione peroxidase that protects cells from oxidative damage.{48903} It is a homotetramer and has an active site containing selenocysteine, glutamine, asparagine, and tryptophan.{48904,67469} mRNA encoding GPX2 has been found predominantly in the liver and gastrointestinal tract and is localized to the nucleus and cytosol, and GPX2 can reduce organic peroxides, such as hydrogen-, tert-butyl-, or cumene hydroperoxide.{67465,67466,67469} It catalyzes the reduction of these reactive oxygen species (ROS) to water or their corresponding non-toxic lipid alcohols by converting glutathione (GSH) to oxidized glutathione (GSSH), reducing intracellular oxidative stress.{67466} GPX2 knockout increases inflammation and tumor growth in a dextran sulfate sodium (DSS) mouse model of inflammation-associated colon carcinogenesis.{67470} Its levels are increased in undifferentiated basal cells, but absent in lineage-restricted luminal progenitors and luminal cells, in normal human breast tissue.{67467} GPX2 levels are decreased in triple-negative- and HER2+ breast cancers, but not in luminal breast cancers, and are negatively correlated with patient survival.{67468} Cayman's GPX2 (human, recombinant) protein can be used for enzyme activity assays.
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    -20
  • 运输温度:
    -20
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  • 产品形式:
    25 mM Tris-HCl, pH 8.0, with 250 mM sodium chloride, 2 mM 2-mercaptoethanol, and 10% glycerol
  • 存储溶液:
  • 有效期:
    365
  • 产地:
    美国
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    ≥95% estimated by SDS-PAGE
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