产品描述:
Tyrosine kinase 2 (TYK2) is a member of the JAK family of non-receptor tyrosine kinases that has a key role in cytokine signaling.{62097,62098} It is composed of an N-terminal FERM homology domain, which mediates protein-protein interactions, a Src-homology 2 (SH2) domain, a catalytically inactive pseudokinase domain, and a catalytically active C-terminal kinase domain.{62097} TYK2 is expressed by a variety of immune cells, including T and B cells, dendritic cells, mast cells, and macrophages, where it associates with numerous cytokine receptor chains, including IFNARI, IL-12Rβ1, IL-10R2, gp130, and IL-13Rα1, to mediate STAT-dependent cytokine signaling.{62098,62097,62099} TYK2 is activated by its phosphorylation, which is induced by ligand-bound cytokine receptors via JAK1 or JAK2-mediated transactivation, and is inhibited by suppressor of cytokine signaling (SOCS) proteins.{62099} TYK2 has roles in numerous immunological processes, including inflammatory and autoimmune diseases, pathogen defense, and allergy, as well as tumor surveillance and cancer.{62097,62099} TYK2 SNPs have been identified in patients with acute myeloid leukemia, and TYK2 polymorphisms have been associated with systemic lupus erythematosus (SLE) and multiple sclerosis in humans.{62097} Cayman's TYK2 (human, recombinant) protein can be used for enzyme activity assays.