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产品名称:
HO-1 Protein
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别名:
Heme oxygenase 1 Protein, HSP32 Protein, Hemox Protein, 32 kD Protein, bK286B10 Protein, D8Wsu38e Protein, heat shock protein 32kD Protein, Heat shock Protein, Heme oxygenase (decycling) 1 Protein, HMOX 1 Protein, Hmox Protein, HMOX1 Protein, HO 1 Protein, HO Protein, HO1
Protein
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产品描述:
Rat Natural HO-1 Full Length Protein
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反应种属:
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宿主来源:
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实验应用:
WB | SDS-PAGE
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靶标/特异性:
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同种型:
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推荐稀释度:
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免疫原:
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免疫原种属:
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克隆性:
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克隆号:
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纯化方式:
Ion-exchange Purified
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偶联:
No tag
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产品浓度:
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表达系统:
Native
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阳性对照:
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保存温度:
-80ºC
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运输温度:
Blue Ice or 4ºC
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细胞定位:
Microsome | Endoplasmic Reticulum
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预期分子量:
~33 kDa
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产品形式:
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存储溶液:
20mM Tris pH7.5, 0.1mM EDTA, 0.1% triton x-100, 0.2% Na cholate, <50mM KCl
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有效期:
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产地:
加拿大
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外观:
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生产商:
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功能与背景:
Heme-oxygenase is a ubiquitous enzyme that catalyzes the initial and rate-limiting steps in heme catabolism yielding equimolar amounts of biliverdin, iron and carbon monoxide. Biliverdin is subsequently converted to bilirubin and the free iron is sequestered to ferritin (1). These products have important physiological effects as carbon monoxide is a potent vasodilator; biliverdin and bilirubin are potent antioxidants; and the free iron increases oxidative stress and regulates the expression of many mRNAs (2). There are three isoforms of heme-oxygenase, HO-1, HO-2 and HO-3; however HO-1 and HO-2 are the major isoforms as they both have been identified in mammals (3). HO-1, also known as heat shock protein 32, is an inducible isoform activated by most oxidative stress inducers, cytokines, inflammatory agents and heat shock. HO-2 is a constitutive isoform which is expressed under homeostatic conditions. HO-1 is also considered to be a cytoprotective factor in that free heme is highly reactive and cytotoxic, and secondly, carbon monoxide is a mediator inhibiting the inflammatory process and bilirubin is a scavenger for reactive oxygen, both of which are the end products of heme catalyzation (4). It has also been shown that HO-1 deficiency may cause reduced stress defense, a pro-inflammatory tendency (5), susceptibility to atherosclerotic lesion formation (6), endothelial cell injury, and growth retardation (7). Up-regulation of HO-1 is therefore said to be one of the major defense mechanisms of oxidative stress (4).
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URL:
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灵敏度:
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检测范围:
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检测方法:
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样本类型:
20mM Tris pH7.5, 0.1mM EDTA, 0.1% triton x-100, 0.2% Na cholate, <50mM KCl
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产品特点:
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纯度:
>90%
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生物活性:
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内毒素水平:
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来源:
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表达方式:
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Accession #:
NP_036712.1
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CAS号:
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分子式:
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溶解度:
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PubChem CID: