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产品名称:
FGF-21 (mouse) (rec.)
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别名:
Fibroblast Growth Factor 21
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产品描述:
Fibroblast growth factor 21 (FGF-21) is a member of the fibroblast growth factor family and has been identified as an important regulator of energy metabolism connecting nutrition, growth, reproduction and longevity. FGF-21 lacks the heparin-binding domain of most FGF proteins, allowing its secretion. FGF-21 is abundantly expressed in adipose tissues, liver and pancreas. In adipose tissue, FGF-21 promotes glucose uptake and oxidation and in liver it replenishes on fasting the tissues with fuel on low nutritional supply. It also induces lipolysis and ketogenesis. FGF-21 acts through FGF receptors (FGFR) associated with the auxiliary protein beta-Klotho. Recently, FGF-21 has been reported to interact directly with the brain circadian clock to coordinate activity and reproduction as part of the adaptation to fasting. Due to its multiple functions of normalizing glucose, lipid and energy homeostasis, FGF-21 represents an attractive novel therapy for type 2 diabetes mellitus and obesity.
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反应种属:
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宿主来源:
HEK 293 cells
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实验应用:
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靶标/特异性:
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同种型:
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推荐稀释度:
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免疫原:
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免疫原种属:
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克隆性:
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克隆号:
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纯化方式:
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偶联:
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产品浓度:
0.1mg/ml after reconstitution
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表达系统:
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阳性对照:
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保存温度:
-20°C
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运输温度:
BLUE ICE
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细胞定位:
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预期分子量:
~24kDa (SDS-PAGE)
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产品形式:
solid
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存储溶液:
Lyophilized. Contains PBS.
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有效期:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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产地:
瑞士
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外观:
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功能与背景:
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URL:
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灵敏度:
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检测范围:
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检测方法:
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样本类型:
Lyophilized. Contains PBS.
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产品特点:
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纯度:
>95% (SDS-PAGE)
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生物活性:
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内毒素水平:
<0.01EU/µg purified protein (LAL test).
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Accession #:
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分子式:
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PubChem CID: