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Cochlin (human) (LCCL domain) (rec.)
品牌： Adipogen
产品货号： AG-40B-0135-C010
规格： 10 ug

报价：
折后价：

数量： - +
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  • 产品名称:
    Cochlin (human) (LCCL domain) (rec.)
  • 别名:
    COCH-5B2 (LCCL domain)
  • 产品描述:
    Cochlin is an extracellular matrix protein expressed in the cochlea and vestibule of the inner ear. Mutations in the cochlin gene are linked to the autosomal-dominant DFNA9 syndrome, a disorder characterized by hearing loss. Cochlin is also expressed in follicular dendritic cells of the spleen and the lymph nodes. The N-terminus of cochlin contains a LCCL domain also present in Factor C, a serine protease of the horseshoe crab Limulus, involved in activating the coagulation cascade in response to LPS. A recent study showed that in response to inflammation, LPS or bacterial infection, cochlin is cleaved by the proteases aggrecanases and secreted into blood circulation. The secreted cochlin (LCCL domain) seems to have a role in local cytokine production, recruitment of immune effector cells and bacterial clearance. Cochlin is secreted as two forms p8 and p18, whereas p18 being the glycosylated form of p8.
  • 反应种属:
  • 宿主来源:
    HEK 293 cells
  • 实验应用:
  • 靶标/特异性:
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  • 推荐稀释度:
  • 免疫原:
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  • 纯化方式:
  • 偶联:
  • 产品浓度:
    0.1mg/ml after reconstitution
  • 表达系统:
  • 阳性对照:
  • 保存温度:
    -20°C
  • 运输温度:
    BLUE ICE
  • 细胞定位:
  • 预期分子量:
    ~8kDa and 18kDa
  • 产品形式:
    solid
  • 存储溶液:
    Lyophilized. Contains PBS.
  • 有效期:
    Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
  • 产地:
    瑞士
  • 外观:
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  • 功能与背景:
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  • 灵敏度:
  • 检测范围:
  • 检测方法:
  • 样本类型:
    Lyophilized. Contains PBS.
  • 产品特点:
  • 纯度:
    >95% (SDS-PAGE)
  • 生物活性:
  • 内毒素水平:
    <0.01EU/µg purified protein (LAL test).
  • 来源:
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  • 分子式:
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