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产品名称:
FNDC4 (rec.) (untagged)
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别名:
Fibronectin Type III Domain-containing Protein 4; Fibronectin Type III Repeat-containing Protein 1
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产品描述:
Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure. FNDC4 is an ortholog of FNDC5 with 50% identity and 86% similarity compared to Irisin. FNDC4 as well as FNDC5 are extremely well conserved between species. The human FNDC4 gene is highly enriched in liver, brain tissue and adipocytes. FNDC4 is a factor with direct therapeutic potential in inflammatory bowel disease and possibly other inflammatory diseases. Recently, a new role of FNDC4 as a hepatokine has been published. Liver primarily controls the circulating levels of FNDC4 showing tight correlation with insulin sensitivity. In addition, a new orphan adhesion G protein-coupled receptor 116 (GPR116) has been identified as a receptor of FNDC4 in white adipose tissue (WAT), thereby establishing an endocrine FNDC4-GPR116 axis in the control of systemic glucose homeostasis. Moreover, the FNDC4-GPR116 axis is impaired in diabetic patients and therapeutic injections of recombinant Fc-FNDC4 into pre-diabetic mice corrected pre-diabetic hyperglycemia.
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反应种属:
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宿主来源:
E. coli
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实验应用:
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靶标/特异性:
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同种型:
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推荐稀释度:
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免疫原:
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偶联:
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产品浓度:
After reconstitution:for 10µg size: 0.1mg/mlfor 50µg size: 1 mg/ml
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表达系统:
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阳性对照:
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保存温度:
-20°C
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运输温度:
BLUE ICE
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细胞定位:
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预期分子量:
~16kDa
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产品形式:
solid
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存储溶液:
Lyophilized. Contains PBS.
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有效期:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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产地:
瑞士
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样本类型:
Lyophilized. Contains PBS.
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产品特点:
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纯度:
>95% (SDS-PAGE)
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生物活性:
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内毒素水平:
<0.01EU/µg purified protein (LAL test; Lonza).
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