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产品名称:
LIF (human) (rec.)
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别名:
Leukemia Inhibitory Factor; Differentiation-stimulating Factor; D Factor; Melanoma-derived LPL Inhibitor
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产品描述:
LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities also include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation and the stimulation of acute-phase protein synthesis in hepatocytes. LIF activates JAK & STAT signaling in human embryonic stem (ES) cells, but this pathway does not maintain pluripotency in these cells, which instead rely on FGF2-mediated ERK signaling. By contrast, mouse ES cells can be maintained by LIF-mediated JAK & STAT signaling. LIF binds to a high affinity heterodimeric receptor complex consisting of two proteins: LIF-R alpha that binds LIF with low affinity and the 130kDa (gp130) subunit that by itself does not bind LIF, but is required for high affinity binding of LIF.
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反应种属:
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宿主来源:
E. coli
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实验应用:
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靶标/特异性:
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同种型:
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推荐稀释度:
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免疫原:
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克隆性:
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克隆号:
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纯化方式:
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偶联:
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产品浓度:
AG-40B-0093-C010/AG-40B-0093-3010: 0.1mg/ml after reconstitution.AG-40B-0093-C100: 1mg/ml after reconstitution.
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表达系统:
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阳性对照:
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保存温度:
-20°C
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运输温度:
BLUE ICE
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细胞定位:
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预期分子量:
~46kDa (SDS-PAGE)
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产品形式:
solid
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存储溶液:
Lyophilized. Contains PBS.
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有效期:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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产地:
瑞士
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外观:
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URL:
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样本类型:
Lyophilized. Contains PBS.
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产品特点:
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纯度:
>95% (SDS-PAGE)
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生物活性:
Maintains pluripotency of mouse and human embryonic stem cells. The LIF (GST-tagged) from AdipoGen has the same activity as cleaved LIF.
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内毒素水平:
<0.05EU/µg purified protein (LAL test; Lonza).
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