CD40L (mouse) (multimeric) (rec.) - 深圳欣博盛生物科技有限公司

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CD40L (mouse) (multimeric) (rec.)

品牌： Adipogen

产品货号： AG-40B-0020-C010

规格： 10 ug

报价：

折后价：

数量： - +

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产品名称:

CD40L (mouse) (multimeric) (rec.)
别名:

MultimericCD40L™; ACRP30headless:CD40L; ACRP30headless:CD154; ACRP30headless:TNFSF5; ADIPOQ-CD40L
产品描述:

The costimulatory molecule CD40, a member of the tumor necrosis factor (TNF) receptor superfamily, critically regulates B cell and T cell function in adaptive immunity and inflammation by interacting with CD40L (CD154). CD40L mediates a range of activities on B cells, including induction of activation-associated surface antigen, entry into cell cycle, isotype switching, immunoglobulin secretion and memory generation. CD40-CD40L interaction also plays important roles in monocyte activation and DC maturation. MultimericCD40L™ is a high activity construct in which two trimeric CD40 ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively simulates the natural membrane-assisted aggregation of CD40L in vivo. It provides a simple and equally potent alternative to CD40L+enhancer combinations. MultimericCD40L™ has shown to suppress alum-induced IL-1beta release and caspase-1 activation in a dose-, CD40- and time dependent manner, without affecting BMDM (Bone marrow-derived macrophages) viability. It also effectively suppressed the inflammasome function triggered by NLRP3 activators. The secretion of caspase-1 independent inflammatory mediators has been shown to be unaltered or even enhanced. MultimericCD40L™ enhances B cell proliferation.
反应种属:
宿主来源:

CHO cells
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产品浓度:

0.1mg/ml after reconstitution
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保存温度:

-20°C
运输温度:

BLUE ICE
细胞定位:
预期分子量:

~35-40kDa
产品形式:

solid
存储溶液:

Lyophilized. Contains PBS.
有效期:

Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
产地:

瑞士
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样本类型:

Lyophilized. Contains PBS.
产品特点:
纯度:

>95% (SDS-PAGE)
生物活性:

Induces B cells activation (as demonstrated by dose-dependent upregulation of CD86).
内毒素水平:

<0.01EU/µg purified protein (LAL test; Lonza).
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