CD274 [B7-H1/PD-L1] (mouse):Fc (mouse) (rec.) (non-lytic) - 深圳欣博盛生物科技有限公司

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CD274 [B7-H1/PD-L1] (mouse):Fc (mouse) (rec.) (non-lytic)

品牌： Adipogen

产品货号： CHI-MF-120PDL1-C100

规格： 100 ug

报价：

折后价：

数量： - +

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产品名称:

CD274 [B7-H1/PD-L1] (mouse):Fc (mouse) (rec.) (non-lytic)
别名:

PD-L1; Programmed Cell Death 1 Ligand Protein 1; PDCD1 Ligand 1; B7-H1; PDL1
产品描述:

Programmed death ligand 1 (PD-L1, B7-H1 or CD274) is a member of the growing B7 family of immune proteins that provide signals for both stimulating and inhibiting T cell activation. CD274 has been identified as one of two ligands for programmed death 1 (PD-1), a member of the CD28 family of immunoreceptors. CD274 is widely expressed in several organs such as heart, skeletal muscle, placenta and lung, and in lower amounts in thymus, spleen, kidney and liver. CD274 expression is upregulated in a small fraction of activated T and B cells and a much larger fraction of activated monocytes. CD274 expression is also induced in dendritic cells and keratinocytes after IFN-gamma stimulation. CD274 expression is also upregulated in a variety of tumor cell lines. Interaction of CD274 with PD-1 results in inhibition of TCR mediated proliferation and cytokine production, suggesting an inhibitory role in regulating immune responses. The CD274 - PD-1 pathway is involved in the negative regulation of some immune responses and may play an important role in the regulation of peripheral tolerance.
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宿主来源:

CHO cells
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保存温度:

-20°C
运输温度:

BLUE ICE
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产品形式:

solid
存储溶液:

Lyophilized from 0.2µm-filtered solution in PBS.
有效期:

Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
产地:

瑞士
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样本类型:

Lyophilized from 0.2µm-filtered solution in PBS.
产品特点:
纯度:

>98% (SDS-PAGE)
生物活性:

Shows the biological function of the CD274 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain.
内毒素水平:

<0.06EU/µg protein (LAL test; Lonza).
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