Tim-3 (mouse):Fc (human) (rec.) - 深圳欣博盛生物科技有限公司

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Tim-3 (mouse):Fc (human) (rec.)

品牌： Adipogen

产品货号： AG-40B-0191-C050

规格： 50 ug

报价：

折后价：

数量： - +

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产品名称:

Tim-3 (mouse):Fc (human) (rec.)
别名:

TIM3; TIMD3; Hepatitis A Virus Cellular Receptor 2; HAVcr-2; T Cell Immunoglobulin and Mucin Domain-containing Protein 3
产品描述:

The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. Tim-3 is also activated by galectin-9, leading to T cells inhibition. Tim-3, a type I transmembrane protein, contains an immunoglobulin and a mucin-like domain in its extracellular portion and a tyrosine phosphorylation motif in its cytoplasmic portion. Tim-3 is preferentially expressed on Th1 and Tc1 cells, and generates an inhibitory signal resulting in apoptosis of Th1 and Tc1 cells. Tim-3 is also expressed on some dendritic cells and can mediate phagocytosis of apoptotic cells and cross-presentation of antigen. Tim-3 functions to inhibit aggressive Th1-mediated auto- and alloimmune responses. Tim-3 pathway blockade by administration of Tim-3:Fc fusion protein accelerates diabetes in nonobese diabetic mice, causes hyperproliferation of Th1 cells and Th1 cytokine release in an experimental autoimmune encephalomyelitis (EAE) model and prevents acquisition of transplantation tolerance induced by costimulation blockade.
反应种属:
宿主来源:

HEK 293 cells
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免疫原:
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产品浓度:

1mg/ml after reconstitution
表达系统:
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保存温度:

-20°C
运输温度:

BLUE ICE
细胞定位:
预期分子量:

~70-75kDa (SDS-PAGE)
产品形式:

solid
存储溶液:

Lyophilized. Contains PBS.
有效期:

Stable for at least 6 months after receipt when stored at -20°C.Working aliquots are stable for up to 3 months when stored at -20°C.
产地:

瑞士
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样本类型:

Lyophilized. Contains PBS.
产品特点:
纯度:

>95% (SDS-PAGE)
生物活性:
内毒素水平:

<0.01EU/µg purified protein (LAL test).
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