PSGL-1 (human):Fc (human) (rec.) - 深圳欣博盛生物科技有限公司

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PSGL-1 (human):Fc (human) (rec.)

品牌： Adipogen

产品货号： AG-40B-0190-C050

规格： 50 ug

报价：

折后价：

数量： - +

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产品名称:

PSGL-1 (human):Fc (human) (rec.)
别名:

P-selectin Glycoprotein Ligand 1; Selectin P Ligand; CD162; SELPLG
产品描述:

P-selectin glycoprotein ligand-1 (PSGL-1) is a 120kda transmembrane homodimer protein that is primarily expressed on lymphoid and myeloid cells, including platelets. PSGL-1 was first identified to regulate the rolling/tethering of neutrophils on activated endothelium through P-selectin binding. PSGL-1 binds P-, E- and L- selectin through the N-terminus of the extracellular domain upon special glycosylation (sialyl Lewis x). PSGL-1 functions in regulating the migration of macrophages/monocytes, plasma B cells, dendritic cells and T cells by selectin engagement. PSGL-1 also regulates localization of macrophages, dendritic cells and B cells in the lamina propria at steady state. Although PSGL-1 is expressed on resting T cells, selectin binding capacity is only acquired during the proliferation/differentiation of effector T cells. In addition to its migratory properties, the adhesion protein PSGL-1 also functions in a selectin-independent manner as a negative regulator of T cell responses in contexts of chronic viral infection, cancer and some autoimmune diseases. For this immune checkpoint function, it has recently been reported that PSGL-1 binds the negative immune checkpoint regulator VISTA (V-domain immunoglobulin suppressor of T cell activation). PSGL-1 expressed on leukocytes binds to multimeric VISTA at acidic pH, but not at the physiological pH 7. This acidic influence of the binding is due to multiple histidine residues protonation located in the VISTA extracellular domain. VISTA - PSGL-1 interaction shows that immune response can be regulated by acidic environments found in tumors. Identification of PSGL-1 - VISTA signaling pathways in T cells could lead to new therapeutic targets that increase immune function, such as in chronic viral infections or in cancer, or attenuate immune function such as in autoimmunity.
反应种属:
宿主来源:

HEK 293 cells
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产品浓度:

1mg/ml after reconstitution
表达系统:
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保存温度:

-20°C
运输温度:

BLUE ICE
细胞定位:
预期分子量:

~95-100kDa (SDS-PAGE)
产品形式:

solid
存储溶液:

Lyophilized. Contains PBS.
有效期:

Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
产地:

瑞士
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样本类型:

Lyophilized. Contains PBS.
产品特点:
纯度:

>95% (SDS-PAGE)
生物活性:

Binds to the human protein VISTA at acidic pH 6.4.
内毒素水平:

<0.01EU/µg purified protein (LAL test).
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