CD137 (human):Fc (mouse) (rec.) - 深圳欣博盛生物科技有限公司

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CD137 (human):Fc (mouse) (rec.)

品牌： Adipogen

产品货号： CHI-HF-211CD137-C100

规格： 100 ug

报价：

折后价：

数量： - +

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产品名称:

CD137 (human):Fc (mouse) (rec.)
别名:

Tumor Necrosis Factor Receptor Superfamily Member 9; TNFRSF9; 4-1BB; 4-1BB Ligand Receptor T Cell; Antigen 4-1BB Homolog; T Cell Antigen ILA; CD137 Antigen; CDw137; ILA; MGC2172
产品描述:

Human CD137 (4-1BB) is a costimulatory molecule of the tumor necrosis factor (TNF) receptor superfamily. The glycoprotein 4-1BB is expressed mainly on activated CD4+ and CD8+ T cells and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. Upon ligand binding, 4-1BB is associated with the tumor receptor-associated factors (TRAF), the adaptor protein and mediates downstream signaling events including the activation of NF-kappaB and cytokine production. 4-1BB signaling either by binding to 4-1BBL or by antibody ligation delivers signals for T cell activation and growth as well as monocyte proliferation and B cell survival, and plays a important role in the amplification of T cell-mediated immune responses. In contrast, it can also enhance activation-induced T cell apoptosis when triggered by engagement of the TCR/CD3 complex. In addition, the 4-1BB/4-1BBL costimulatory pathway has been shown to augment secondary CTL responses to several viruses and increase antitumor immunity. 4-1BB is therefore a promising candidate for immunotherapy of human cancer.
反应种属:
宿主来源:

HEK 293 cells
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保存温度:

-20°C
运输温度:

BLUE ICE
细胞定位:
预期分子量:

~55kDa (SDS-PAGE)
产品形式:

solid
存储溶液:

Lyophilized from 0.2µm-filtered solution in PBS.
有效期:

Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
产地:

瑞士
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样本类型:

Lyophilized from 0.2µm-filtered solution in PBS.
产品特点:
纯度:

>98% (SDS-PAGE)
生物活性:

Measured by its binding ability in a functional ELISA.
内毒素水平:

<5EU/mg protein (LAL test; Lonza).
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